ABSTRACT
Google and Apple jointly introduced a digital contact tracing technology and an API called "exposure notification,'' to help health organizations and governments with contact tracing. The technology and its interplay with security and privacy constraints require investigation. In this study, we examine and analyze the security, privacy, and reliability of the technology with actual and typical scenarios (and expected typical adversary in mind), and quite realistic use cases. We do it in the context of Virginia's COVIDWISE app. This experimental analysis validates the properties of the system under the above conditions, a result that seems crucial for the peace of mind of the exposure notification technology adopting authorities, and may also help with the system's transparency and overall user trust. © 2022 Owner/Author.
ABSTRACT
Rare cases of vaccine-induced Immune thrombocytopenia and thrombosis (VITT) are being identified after vaccination with the SARS-CoV-2 Oxford-AstraZeneca vaccination. We report on two such patients with associated adrenal involvement, which is now being recognised. Both patients presented with abdominal pain, back pain and vomiting. Case 1 was a 46-year-old male who had received the first dose of the Oxford-AstraZeneca vaccination 8 days earlier. Imaging demonstrated a number of serious thrombotic complications including evolving bilateral adrenal haemorrhage (right adrenal haemorrhage identified at presentation, with the left-sided changes only evident on day 4 of the admission). Case 2 was a 38-year-old female who had received the first dose of Oxford-AstraZeneca vaccination 11 days prior. Imaging demonstrated left renal vein thrombosis and left adrenal infarction. VITT was diagnosed in both cases given these changes and other consistent haematological findings. Both patients were treated empirically for adrenal insufficiency, a diagnosis subsequently confirmed in case 1. We report these two cases of VITT presenting with adrenal complications (haemorrhage and infarction) after Oxford-AstraZeneca vaccination to highlight the association and the need for prompt management of co-existing adrenal insufficiency, especially given the potential for evolving adrenal involvement.